PMS AND PMDD
INFERTILITY AND MENTAL HEALTH
Furmli H, Seeto RA, Hewko SL, Dalfen A, Jones CA, Murphy KE, Bocking A. J Obstet Gynaecol Can. 2019 Jul 25.
Women who conceived using ART reported decreased rates of depressive symptoms, perceived stress, and generalized anxiety during the second trimester of pregnancy compared with women who had spontaneously conceived pregnancies, and both groups experienced similar mental health status earlier in gestation and in the postpartum period.
PSYCHIATRIC ILLNESS DURING PREGNANCY
Naki? Radoš S, Matijaš M, Kuhar L, An?elinovi? M, Ayers S. Psychol Trauma. 2019 Aug 1.
City Birth Trauma Scale is a recently developed scale specifically designed for evaluation of posttraumatic stress disorder (PTSD) following childbirth based on the DSM-5 criteria.
MEDICATIONS AND PREGNANCY
Margulis AV, Hernandez-Diaz S, McElrath T, Rothman KJ, Plana E, Almqvist C, D’Onofrio BM, Oberg AS. PLoS One. 2019 Aug 5. Free Article
Relative to lamotrigine, valproic acid and carbamazepine were associated with smaller head circumference.
Freeman MP, Goez-Mogollon L, Sosinsky AZ, Church TR, McElheny SA, Viguera AC, Cohen LS. J Psychosom Res. 2019 Aug.
Women with obesity were at higher risk for gestational diabetes (p?=?0.011; OR:3.23; 95% CI:1.30,7.98), as were women in the overweight BMI category (p?=?0.003; OR:3.77; 95% CI:1.58,9.00). Among women with obesity, there was a tendency for a higher C-section rate (p?=?0.07) compared to women in the normal-weight BMI category. Other outcomes were not significantly different among groups.
Galbally M, Frayne J, Watson SJ, Snellen M. Eur Neuropsychopharmacol. 2019 Jan;29(1):57-65.
Bogi E, Belovicová K, Ujhazy E, Mach M, Koprdova R, Zilava L, Garafová A, Jezova D, Dubovicky M. Behav Pharmacol. 2018 Aug;29(5):445-452.
In this study carried out in rats, the animals exposed through their mothers to venlafaxine, particularly at the lowest and middle doses, were less anxious and less depressive in several relevant behavioral tests. At clinically relevant doses, venlafaxine did not alter circulating levels of corticosterone and aldosterone in the adult offspring. In general, the consequences of venlafaxine were dose dependent and more apparent in females. Together, these results suggest that prenatal and early postnatal exposure to venlafaxine may affect functional development of the brain, though not necessarily in a negative way.
POSTPARTUM PSYCHIATRIC ILLNESS
Pataky EA, Ehlert U. Arch Womens Ment Health. 2019 Jul 26.
Women with a history of depression were twice more likely to show peripartum depressive symptoms than women without a history of depression. A history of symptoms of PMS/PMDD prior to the current pregnancy was associated with increased odds of peripartum depressive symptoms (p values <?.05).
Docherty A, Najjar R, Combs S, Woolley R, Stoyles S.
J Am Assoc Nurse Pract. 2019 Jul 31.
Of the 55 respondents, 29% followed the AAP recommendations and screened at well-child visits; the most common screening barriers were limited knowledge and/or availability of referral services. Physicians were more likely to meet any recommended guidelines than nurse practitioners (NPs).
Li HJ, Martinez PE, Li X, Schenkel LA, Nieman LK, Rubinow DR, Schmidt PJ. Arch Womens Ment Health. 2019 Aug 1. d
Researchers were unable to demonstrate a significant therapeutic benefit of transdermal estradiol compared with placebo in PPD; however, the study was limited by under-recruitment and loss to follow-up.
Gan Y, Xiong R, Song J, Xiong X, Yu F, Gao W, Hu H, Zhang J, Tian Y, Gu X, Zhang J, Chen D. BMC Psychiatry. 2019 Jul 29;19(1):232. Free Article
Low perceived social support early in pregnancy was associated with an increased risk of postpartum depressive symptoms. Thus, it is possible that interventions to increase supports may decrease risk for PPD.
MEDICATIONS AND BREASTFEEDING
PERINATAL SUBSTANCE USE DISORDERS
Lee SJ, Pritchard VE, Austin NC, Henderson JMT, Woodward LJ. J Dev Behav Pediatr. 2019 Aug 1.
Children born to opioid-dependent mothers are at high risk of impaired school readiness, with multiple domain problems being common. Impaired school readiness was associated with greater maternal prenatal substance use, higher social risk, male sex, and lower-quality caregiving environments.
Caritis SN, Panigrahy A. Am J Obstet Gynecol 2019.
In light of the recent data on medically supervised withdrawal and the emerging evidence suggesting adverse effects of opioids on the developing fetal brain, a new paradigm of care is needed that includes the preferred option of medication-assisted treatment but also the option of medically supervised opioid withdrawal for a select group of women.
Yeoh SL, Eastwood J, Wright IM, Morton R, Melhuish E, Ward M, Oei JL. JAMA Netw Open. 2019 Jul 3. Free Article
Prenatal opioid exposure appeared to be negatively associated with neurocognitive and physical development from age 6 months, and this association persisted until adolescence.
Bakhireva LN, Holbrook BD, Shrestha S, Leyva Y, Ashley M, Cano S, Lowe J, Stephen JM, Leeman L. Early Hum Dev. 2019 Jan;128:69-76.
There was little to no effect of MAT and pharmacological treatment of neonatal opioid withdrawal symptoms on infant neurodevelopmental and behavioral outcomes at 5-8?months of age.
MATERNAL MENTAL HEALTH AND CHILD OUTCOMES
Galbally M, van Rossum EFC, Watson SJ, de Kloet ER, Lewis AJ. Psychoneuroendocrinology. 2019 Jul 29;1
Anxiety, stress and antidepressant use were not associated with maternal HCC. Independently, higher maternal 3rd trimester maternal depressive and anxiety symptoms were associated with lower infant cortisol response at 12 months of age. A higher number of postpartum stressful events was associated with lower infant cortisol response. Lower infant stress reactivity was associated with higher externalizing symptoms at 12 months of age.