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Hyperbilirubinemia is the accumulation of bilirubin, a brownish-yellow compound that is formed when old or damaged red blood cells are broken down. Normally, bilirubin is chemically altered by the liver so that it can be safely excreted in stool and urine. In anyone, however, the condition may be indicative of disease. Complications may occur, primarily in newborns, if bilirubin levels become toxic in the brain. This can lead to a condition known as kernicterus in which seizures, irreversible brain damage, and death can occur. There are many different reasons why hyperbilirubinemia may occur. The causes can be broadly broken down by the type of bilirubin involved.